K858 CAS：72926-24-0

K-858 is a novel inhibitor of mitotic kinesin Eg5 and antitumor agent,induces cell death in cancer cells.K858 blocked centrosome separation,activated the spindle checkpoint,and induced mitotic arrest in cells accompanied by the formation of monopolar spindles.Long-term continuous treatment of cancer cells with K858 resulted in antiproliferative effects through the induction of mitotic cell death,and polyploidization followed by senescence.K858 exhibited potent antitumor activity in xenograft models of cancer,and induced the accumulation of mitotic cells with monopolar spindles in tumor tissues.

msds---K858